Blocking of valinomycin-mediated bilayer membrane conductance by substituted benzimidazoles
نویسندگان
چکیده
منابع مشابه
Inhibition of heme synthesis by methyl-substituted benzimidazoles in vitro.
Emerson and associates (1) noted that 2,5-dimethylbenzimidazole appeared to act as a growth depressant when fed to rats in tests of compounds for vitamin Blz-like activity. This property was not exhibited by benzimidazole or any of the other monoor dimethylbenzimidazoles studied. They remarked that 2,5-dimethylbenzimidazole might have “inhibitor activity.” 2,5-Dimethylbenzimidazole inhibited re...
متن کاملSoluble Amyloid Oligomers Increase Bilayer Conductance by Altering Dielectric Structure
The amyloid hypothesis of Alzheimer's toxicity has undergone a resurgence with increasing evidence that it is not amyloid fibrils but a smaller oligomeric species that produces the deleterious results. In this paper we address the mechanism of this toxicity. Only oligomers increase the conductance of lipid bilayers and patch-clamped mammalian cells, producing almost identical current-voltage cu...
متن کاملBilayer-thickness-mediated interactions between integral membrane proteins.
Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large-scale organization of integral membrane protei...
متن کاملDynamics of Bilayer Membrane
The theory combines the Rouse model for a single chain with the liquid crystal theory for bilayer membrane developed by Marcelja. Thus the forces acting on a bead within a chain are spring forces, Brownian force and dissipative or viscous force which appear in Rousetheory plus the liquid crystal and lateral pressure forces. The dynamic viscosity of the system is calculated. 1 . Introduction. Ex...
متن کاملSorting of integral membrane proteins mediated by curvature-dependent protein-lipid bilayer interaction.
Cell membrane proteins, both bound and integral, are known to preferentially accumulate at membrane locations with curvatures favorable to their shape. This is mainly due to the curvature dependent interaction between membrane proteins and their lipid environment. Here, we analyze the effects of the protein-lipid bilayer interaction energy due to mismatch between the protein shape and the princ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1976
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(76)85671-8